Profile copy/assign - but Outlook, IE won't start

The problem, with Outlook at least, seems to be incorrect permissions in the registry - in particular HKCU\Software\Microsoft\Windows NT\CurrentVersion\Windows Messaging Subsystem\Profiles
(Even the Mail control Panel doesn't run).

I tried again to (delete and) re-copy the local user profile, assigning it at the same time to the domain user. The copy completes, but then the Copy To dialog doesn't close - it sits there as it was. If I click OK it warns that the profile already exists (i.e. it's going to copy it again), so I click Cancel? Then do an Assign to the domain user as a separate step.

I'm doing this logged in as the domain Administrator - is this the correct account to use? (My own account is a local Administrator, but this is the profile I'm copying, so I figured it was safer to do it from the domain Administrator account?)

So I log in again to the [copied] domain account - IE now seems to work, but a couple of other apps (incl. Adobe) give errors on login, and Outlook still won't start.

Do you have any suggestions/corrections to the above - at the moment UPM isn't looking like it's going to be something we can use.

Thanks for the reply. I decided to try User Profile Manager because I was nervous about anything going wrong with a Wizard migration - i.e. in case of problems the users would still be able to log into their old local account.